Targeting grp78 as a basis for enhanced glioma cells killing by anti-tfr antibody
نویسندگان
چکیده
منابع مشابه
Importance of Anti-GRP78 Antibody in Pre-Eclampsia
Background: Preeclampsia (PE) is a pregnancy specific syndrome that is associated with high maternal and fetal morbidity and mortality. Glucose regulated protein78 (GRP78) is an Endoplasmic Reticulum (ER) protein which is expressed on the cell surfaces of trophoblast cells under stress or hypoxic condition. GRP78 has a role in aggressive behavior of invasive cells and may play a role in normal ...
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Chordoma, a rare bone tumor derived from the notochord, has been shown to be resistant to conventional therapies. Checkpoint inhibition has shown great promise in immune-mediated therapy of diverse cancers. The anti-PD-L1 mAb avelumab is unique among checkpoint inhibitors in that it is a fully human IgG1 capable of mediating antibody-dependent cell-mediated cytotoxicity (ADCC) of PD-L1-expressi...
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High-grade glioma is a highly malignant and metastatic brain cancer, resistant to many existing anticancer treatments. In such glioma cancer cells, the glucose-regulated protein 78 kDa (GRP78) is particularly highly up-regulated. Former studies have thus targeted mutation-free GRP78 not only to detect glioma cancer cells specifically but also to enhance cytotoxic effect. We focus on cell surfac...
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Glioblastoma multiforme, the most aggressive primary brain tumor, is maintained by a subpopulation of glioma cells with self-renewal properties that are able to recapitulate the entire tumor even after surgical resection or chemo-radiotherapy. This typifies the vast heterogeneity of this tumor with the two extremes represented on one end by the glioma stemlike cells (GSC) and on the other by th...
متن کاملimportance of anti-grp78 antibody in pre-eclampsia
background: preeclampsia (pe) is a pregnancy specific syndrome that is associated with high maternal and fetal morbidity and mortality. glucose regulated protein78 (grp78) is an endoplasmic reticulum (er) protein which is expressed on the cell surfaces of trophoblast cells under stress or hypoxic condition. grp78 has a role in aggressive behavior of invasive cells and may play a role in normal ...
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ژورنال
عنوان ژورنال: Turkish Neurosurgery
سال: 2017
ISSN: 1019-5149
DOI: 10.5137/1019-5149.jtn.20339-17.1